Medications and Hypothalamic Obesity – What Does the Literature Say? Hypothalamic obesity is considered a treatment-resistant condition. A limited number of studies have looked at pharmacological treatments for hypothalamic obesity. Although no one medication can “cure” hypothalamic obesity, the following medications MAY help, although more studies are needed. Dextroamphetamine, long acting Naltrexone Intranasal Oxytocin Carbetocin